Type 1 And Type 2 Diabetes 3d Model. This rather limited dataset is supportive of the conclusion that genes determining the level of ros stress are important in both type 1 and type 2 diabetes. Hayes 1 sang su oh 1 matthias kretzler 2 3 4 and eva l.
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The type 1 diabetes simulation model is built around a series of key health states and interlinking dependencies. This rather limited dataset is supportive of the conclusion that genes determining the level of ros stress are important in both type 1 and type 2 diabetes. The induced type 1 dm miniature swine closely mimics type 1 dm of humans.
However in the mouse models of each disease form chosen one might infer that ros mediated damage to β cells may be primary in the type 1 diabetes model but secondary in the type 2.
The db db mouse is a more aggressive model of type 2 diabetes that will progress to pancreatic failure and frank diabetes. In addition the choice will be influenced by the study design for example whether the aim is to understand more about the pathogenesis prevent disease onset or to treat the disease king and bowe 2016. Rodent models of diabetic cardiomyopathy. The db db mouse is a more aggressive model of type 2 diabetes that will progress to pancreatic failure and frank diabetes.
